Warburg Micro is considered a spectrum disease. While many symptoms are similar, they may be more mild or more severe in each child.

Warburg Micro should be suspected in any child that has congenital cataracts with micropthalmia and significant developmental day, especially in males with hypogandism.

Symptoms

At Birth

Warburg Micro, SPG 69, may go unnoticed at birth. Microcephaly, jaundice and feeding issues range from mild to severe.

 All children that have the syndrome are born with congenital cataracts- though medical professionals may miss them if a red reflex test is not done.

Symptoms

Early Childhood

Symptoms

Adolescence and beyond

What You Can Do

Connect with researchers or find useful guides for navigating the diagnosis

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Get a Diagnosis

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Handley M, Sheridan E. RAB18 Deficiency. In: GeneReviews®. University of Washington, Seattle, Seattle (WA); 1993. PMID: 29300443. https://www.ncbi.nlm.nih.gov/books/NBK475670/

Last updated: 3/27/2022

Disclaimer: Families should consult a medical professional for genetic diagnosis, management and health concerns. We provide external links to help families and caregivers find additional information- this should not imply our endorsement or responsibility for their content.