WMS Facts

What is the life expectancy for Warburg Micro?

Secondary Complications

There is no research that indicates that Warburg Micro Syndrome (RAB18 associated hereditary spastic paralegia) reduces life expectancy.

But secondary complications can be life-threatening.  

Respiratory infections

Individuals with this disorder are prone to respiratory infection due to reduced mobility and aspiration.

Risk of injury

Reduced mobility, hormonal imbalance, and anticonvulsants increase the risk of osteoporosis. This, in combination with the need for caregivers to assist in movement, increases the risk of injury.

Furthermore, patients may be unable to effectively communicate the cause and severity of distress resulting in its progression.

Learn more about symptoms here. 

Warburg Micro is not known to reduce life expectancy.

Handley M, Sheridan E. RAB18 Deficiency. In: GeneReviews®. University of Washington, Seattle, Seattle (WA); 1993. PMID: 29300443. https://www.ncbi.nlm.nih.gov/books/NBK475670/

Last updated: 3/27/2022

Disclaimer: Families should consult a medical professional for genetic diagnosis, management and health concerns. We provide external links to help families and caregivers find additional information- this should not imply our endorsement or responsibility for their content. 

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